Ketamine: stimulating antidepressant treatment?
Identifieur interne : 000038 ( Main/Exploration ); précédent : 000037; suivant : 000039Ketamine: stimulating antidepressant treatment?
Auteurs : Gin S. Malhi [Australie] ; Yulisha Byrow [Australie] ; Frederick Cassidy [États-Unis] ; Andrea Cipriani [Royaume-Uni] ; Koen Demyttenaere [Belgique] ; Mark A. Frye [États-Unis] ; Michael Gitlin [États-Unis] ; Sidney H. Kennedy [Canada] ; Terence A. Ketter [États-Unis] ; Raymond W. Lam [Canada] ; Rupert Mcshane [Royaume-Uni] ; Alex J. Mitchell [Royaume-Uni] ; Michael J. Ostacher [États-Unis] ; Sakina J. Rizvi [Canada] ; Michael E. Thase [États-Unis] ; Mauricio Tohen [États-Unis]Source :
- BJPsych open ; 2016.
Abstract
The appeal of ketamine - in promptly ameliorating depressive symptoms even in those with non-response - has led to a dramatic increase in its off-label use. Initial promising results await robust corroboration and key questions remain, particularly concerning its long-term administration. It is, therefore, timely to review the opinions of mood disorder experts worldwide pertaining to ketamine's potential as an option for treating depression and provide a synthesis of perspectives - derived from evidence and clinical experience - and to consider strategies for future investigations.
DOI: 10.1192/bjpo.bp.116.002923
PubMed: 27703782
Affiliations:
- Australie, Belgique, Canada, Royaume-Uni, États-Unis
- Angleterre, Californie, Caroline du Nord, Minnesota, Nouveau-Mexique, Ontario, Oxfordshire, Pennsylvanie
- Oxford, Toronto
- Université d'Oxford, Université de Toronto
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Malhi</name><affiliation wicri:level="1"><nlm:affiliation>, MD, Department of Psychiatry, Kolling Institute, Sydney Medical School, University of Sydney, Sydney, NSW, Australia; CADE Clinic, Department of Psychiatry, Royal North Shore Hospital, St Leonards, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>, MD, Department of Psychiatry, Kolling Institute, Sydney Medical School, University of Sydney, Sydney, NSW, Australia; CADE Clinic, Department of Psychiatry, Royal North Shore Hospital, St Leonards, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Byrow, Yulisha" sort="Byrow, Yulisha" uniqKey="Byrow Y" first="Yulisha" last="Byrow">Yulisha Byrow</name><affiliation wicri:level="1"><nlm:affiliation>, PhD, CADE Clinic, Department of Psychiatry, Royal North Shore Hospital, St Leonards, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>, PhD, CADE Clinic, Department of Psychiatry, Royal North Shore Hospital, St Leonards, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Cassidy, Frederick" sort="Cassidy, Frederick" uniqKey="Cassidy F" first="Frederick" last="Cassidy">Frederick Cassidy</name><affiliation wicri:level="2"><nlm:affiliation>, MD, Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>, MD, Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Cipriani, Andrea" sort="Cipriani, Andrea" uniqKey="Cipriani A" first="Andrea" last="Cipriani">Andrea Cipriani</name><affiliation wicri:level="4"><nlm:affiliation>, PhD, Department of Psychiatry, University of Oxford, Oxford, UK; Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>, PhD, Department of Psychiatry, University of Oxford, Oxford, UK; Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Demyttenaere, Koen" sort="Demyttenaere, Koen" uniqKey="Demyttenaere K" first="Koen" last="Demyttenaere">Koen Demyttenaere</name><affiliation wicri:level="1"><nlm:affiliation>, PhD, KU Leuven, Department of Neurosciences, Research Group of Psychiatry, University Psychiatric Center, Leuven, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>, PhD, KU Leuven, Department of Neurosciences, Research Group of Psychiatry, University Psychiatric Center, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Frye, Mark A" sort="Frye, Mark A" uniqKey="Frye M" first="Mark A" last="Frye">Mark A. Frye</name><affiliation wicri:level="2"><nlm:affiliation>, MD, Psychiatry, Mayo Clinic Depression Center, Mayo Clinic, Rochester, MN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>, MD, Psychiatry, Mayo Clinic Depression Center, Mayo Clinic, Rochester, MN</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Gitlin, Michael" sort="Gitlin, Michael" uniqKey="Gitlin M" first="Michael" last="Gitlin">Michael Gitlin</name><affiliation wicri:level="2"><nlm:affiliation>, MD, Department of Psychiatry, Geffen School of Medicine at UCLA, Los Angeles, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>, MD, Department of Psychiatry, Geffen School of Medicine at UCLA, Los Angeles, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Kennedy, Sidney H" sort="Kennedy, Sidney H" uniqKey="Kennedy S" first="Sidney H" last="Kennedy">Sidney H. Kennedy</name><affiliation wicri:level="1"><nlm:affiliation>, MD, Arthur Sommer Rotenberg Chair in Suicide & Depression Studies, St. Michael's Hospital; Professor of Psychiatry, University Health Network and Institute of Medical Science, University of Toronto, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>, MD, Arthur Sommer Rotenberg Chair in Suicide & Depression Studies, St. Michael's Hospital; Professor of Psychiatry, University Health Network and Institute of Medical Science, University of Toronto, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Ketter, Terence A" sort="Ketter, Terence A" uniqKey="Ketter T" first="Terence A" last="Ketter">Terence A. Ketter</name><affiliation wicri:level="2"><nlm:affiliation>, MD, Psychiatry and Behavioral Sciences, Chief, Bipolar Disorders Clinic, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>, MD, Psychiatry and Behavioral Sciences, Chief, Bipolar Disorders Clinic, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Lam, Raymond W" sort="Lam, Raymond W" uniqKey="Lam R" first="Raymond W" last="Lam">Raymond W. Lam</name><affiliation wicri:level="1"><nlm:affiliation>, MD, Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>, MD, Department of Psychiatry, University of British Columbia, Vancouver, BC</wicri:regionArea><wicri:noRegion>BC</wicri:noRegion></affiliation></author><author><name sortKey="Mcshane, Rupert" sort="Mcshane, Rupert" uniqKey="Mcshane R" first="Rupert" last="Mcshane">Rupert Mcshane</name><affiliation wicri:level="3"><nlm:affiliation>, MD, Oxford Health NHS Foundation Trust, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>, MD, Oxford Health NHS Foundation Trust, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Mitchell, Alex J" sort="Mitchell, Alex J" uniqKey="Mitchell A" first="Alex J" last="Mitchell">Alex J. Mitchell</name><affiliation wicri:level="1"><nlm:affiliation>, MD, Liaison Psychiatry and Psycho-Oncology, University of Leicester, Leicester, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>, MD, Liaison Psychiatry and Psycho-Oncology, University of Leicester, Leicester</wicri:regionArea><wicri:noRegion>Leicester</wicri:noRegion></affiliation></author><author><name sortKey="Ostacher, Michael J" sort="Ostacher, Michael J" uniqKey="Ostacher M" first="Michael J" last="Ostacher">Michael J. Ostacher</name><affiliation wicri:level="2"><nlm:affiliation>, MD, Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>, MD, Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Rizvi, Sakina J" sort="Rizvi, Sakina J" uniqKey="Rizvi S" first="Sakina J" last="Rizvi">Sakina J. Rizvi</name><affiliation wicri:level="4"><nlm:affiliation>, PhD, Li Ka Shing Knowledge Institute, ASR Suicide and Depression Studies Program, St. Michael's Hospital; Department of Psychiatry and Institute of Medical Science, University of Toronto, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>, PhD, Li Ka Shing Knowledge Institute, ASR Suicide and Depression Studies Program, St. Michael's Hospital; Department of Psychiatry and Institute of Medical Science, University of Toronto, Toronto, ON</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Thase, Michael E" sort="Thase, Michael E" uniqKey="Thase M" first="Michael E" last="Thase">Michael E. Thase</name><affiliation wicri:level="2"><nlm:affiliation>, MD, Department of Psychiatry, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA, USA; Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>, MD, Department of Psychiatry, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA, USA; Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Tohen, Mauricio" sort="Tohen, Mauricio" uniqKey="Tohen M" first="Mauricio" last="Tohen">Mauricio Tohen</name><affiliation wicri:level="2"><nlm:affiliation>, MD, Professor and Chairman of the Department of Psychiatry & Behavioural Sciences at the University of New Mexico, Albuquerque, NM, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>, MD, Professor and Chairman of the Department of Psychiatry & Behavioural Sciences at the University of New Mexico, Albuquerque, NM</wicri:regionArea><placeName><region type="state">Nouveau-Mexique</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27703782</idno><idno type="pmid">27703782</idno><idno type="doi">10.1192/bjpo.bp.116.002923</idno><idno type="wicri:Area/PubMed/Corpus">000013</idno><idno type="wicri:Area/PubMed/Curation">000013</idno><idno type="wicri:Area/PubMed/Checkpoint">000013</idno><idno type="wicri:Area/Ncbi/Merge">000484</idno><idno type="wicri:Area/Ncbi/Curation">000484</idno><idno type="wicri:Area/Ncbi/Checkpoint">000484</idno><idno type="wicri:Area/Main/Merge">000038</idno><idno type="wicri:Area/Main/Curation">000038</idno><idno type="wicri:Area/Main/Exploration">000038</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Ketamine: stimulating antidepressant treatment?</title><author><name sortKey="Malhi, Gin S" sort="Malhi, Gin S" uniqKey="Malhi G" first="Gin S" last="Malhi">Gin S. Malhi</name><affiliation wicri:level="1"><nlm:affiliation>, MD, Department of Psychiatry, Kolling Institute, Sydney Medical School, University of Sydney, Sydney, NSW, Australia; CADE Clinic, Department of Psychiatry, Royal North Shore Hospital, St Leonards, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>, MD, Department of Psychiatry, Kolling Institute, Sydney Medical School, University of Sydney, Sydney, NSW, Australia; CADE Clinic, Department of Psychiatry, Royal North Shore Hospital, St Leonards, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Byrow, Yulisha" sort="Byrow, Yulisha" uniqKey="Byrow Y" first="Yulisha" last="Byrow">Yulisha Byrow</name><affiliation wicri:level="1"><nlm:affiliation>, PhD, CADE Clinic, Department of Psychiatry, Royal North Shore Hospital, St Leonards, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>, PhD, CADE Clinic, Department of Psychiatry, Royal North Shore Hospital, St Leonards, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Cassidy, Frederick" sort="Cassidy, Frederick" uniqKey="Cassidy F" first="Frederick" last="Cassidy">Frederick Cassidy</name><affiliation wicri:level="2"><nlm:affiliation>, MD, Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>, MD, Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Cipriani, Andrea" sort="Cipriani, Andrea" uniqKey="Cipriani A" first="Andrea" last="Cipriani">Andrea Cipriani</name><affiliation wicri:level="4"><nlm:affiliation>, PhD, Department of Psychiatry, University of Oxford, Oxford, UK; Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>, PhD, Department of Psychiatry, University of Oxford, Oxford, UK; Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Demyttenaere, Koen" sort="Demyttenaere, Koen" uniqKey="Demyttenaere K" first="Koen" last="Demyttenaere">Koen Demyttenaere</name><affiliation wicri:level="1"><nlm:affiliation>, PhD, KU Leuven, Department of Neurosciences, Research Group of Psychiatry, University Psychiatric Center, Leuven, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>, PhD, KU Leuven, Department of Neurosciences, Research Group of Psychiatry, University Psychiatric Center, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Frye, Mark A" sort="Frye, Mark A" uniqKey="Frye M" first="Mark A" last="Frye">Mark A. Frye</name><affiliation wicri:level="2"><nlm:affiliation>, MD, Psychiatry, Mayo Clinic Depression Center, Mayo Clinic, Rochester, MN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>, MD, Psychiatry, Mayo Clinic Depression Center, Mayo Clinic, Rochester, MN</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Gitlin, Michael" sort="Gitlin, Michael" uniqKey="Gitlin M" first="Michael" last="Gitlin">Michael Gitlin</name><affiliation wicri:level="2"><nlm:affiliation>, MD, Department of Psychiatry, Geffen School of Medicine at UCLA, Los Angeles, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>, MD, Department of Psychiatry, Geffen School of Medicine at UCLA, Los Angeles, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Kennedy, Sidney H" sort="Kennedy, Sidney H" uniqKey="Kennedy S" first="Sidney H" last="Kennedy">Sidney H. Kennedy</name><affiliation wicri:level="1"><nlm:affiliation>, MD, Arthur Sommer Rotenberg Chair in Suicide & Depression Studies, St. Michael's Hospital; Professor of Psychiatry, University Health Network and Institute of Medical Science, University of Toronto, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>, MD, Arthur Sommer Rotenberg Chair in Suicide & Depression Studies, St. Michael's Hospital; Professor of Psychiatry, University Health Network and Institute of Medical Science, University of Toronto, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Ketter, Terence A" sort="Ketter, Terence A" uniqKey="Ketter T" first="Terence A" last="Ketter">Terence A. Ketter</name><affiliation wicri:level="2"><nlm:affiliation>, MD, Psychiatry and Behavioral Sciences, Chief, Bipolar Disorders Clinic, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>, MD, Psychiatry and Behavioral Sciences, Chief, Bipolar Disorders Clinic, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Lam, Raymond W" sort="Lam, Raymond W" uniqKey="Lam R" first="Raymond W" last="Lam">Raymond W. Lam</name><affiliation wicri:level="1"><nlm:affiliation>, MD, Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>, MD, Department of Psychiatry, University of British Columbia, Vancouver, BC</wicri:regionArea><wicri:noRegion>BC</wicri:noRegion></affiliation></author><author><name sortKey="Mcshane, Rupert" sort="Mcshane, Rupert" uniqKey="Mcshane R" first="Rupert" last="Mcshane">Rupert Mcshane</name><affiliation wicri:level="3"><nlm:affiliation>, MD, Oxford Health NHS Foundation Trust, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>, MD, Oxford Health NHS Foundation Trust, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Mitchell, Alex J" sort="Mitchell, Alex J" uniqKey="Mitchell A" first="Alex J" last="Mitchell">Alex J. Mitchell</name><affiliation wicri:level="1"><nlm:affiliation>, MD, Liaison Psychiatry and Psycho-Oncology, University of Leicester, Leicester, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>, MD, Liaison Psychiatry and Psycho-Oncology, University of Leicester, Leicester</wicri:regionArea><wicri:noRegion>Leicester</wicri:noRegion></affiliation></author><author><name sortKey="Ostacher, Michael J" sort="Ostacher, Michael J" uniqKey="Ostacher M" first="Michael J" last="Ostacher">Michael J. Ostacher</name><affiliation wicri:level="2"><nlm:affiliation>, MD, Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>, MD, Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Rizvi, Sakina J" sort="Rizvi, Sakina J" uniqKey="Rizvi S" first="Sakina J" last="Rizvi">Sakina J. Rizvi</name><affiliation wicri:level="4"><nlm:affiliation>, PhD, Li Ka Shing Knowledge Institute, ASR Suicide and Depression Studies Program, St. Michael's Hospital; Department of Psychiatry and Institute of Medical Science, University of Toronto, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>, PhD, Li Ka Shing Knowledge Institute, ASR Suicide and Depression Studies Program, St. Michael's Hospital; Department of Psychiatry and Institute of Medical Science, University of Toronto, Toronto, ON</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Thase, Michael E" sort="Thase, Michael E" uniqKey="Thase M" first="Michael E" last="Thase">Michael E. Thase</name><affiliation wicri:level="2"><nlm:affiliation>, MD, Department of Psychiatry, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA, USA; Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>, MD, Department of Psychiatry, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA, USA; Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Tohen, Mauricio" sort="Tohen, Mauricio" uniqKey="Tohen M" first="Mauricio" last="Tohen">Mauricio Tohen</name><affiliation wicri:level="2"><nlm:affiliation>, MD, Professor and Chairman of the Department of Psychiatry & Behavioural Sciences at the University of New Mexico, Albuquerque, NM, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>, MD, Professor and Chairman of the Department of Psychiatry & Behavioural Sciences at the University of New Mexico, Albuquerque, NM</wicri:regionArea><placeName><region type="state">Nouveau-Mexique</region></placeName></affiliation></author></analytic><series><title level="j">BJPsych open</title><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The appeal of ketamine - in promptly ameliorating depressive symptoms even in those with non-response - has led to a dramatic increase in its off-label use. Initial promising results await robust corroboration and key questions remain, particularly concerning its long-term administration. It is, therefore, timely to review the opinions of mood disorder experts worldwide pertaining to ketamine's potential as an option for treating depression and provide a synthesis of perspectives - derived from evidence and clinical experience - and to consider strategies for future investigations.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Belgique</li><li>Canada</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Californie</li><li>Caroline du Nord</li><li>Minnesota</li><li>Nouveau-Mexique</li><li>Ontario</li><li>Oxfordshire</li><li>Pennsylvanie</li></region><settlement><li>Oxford</li><li>Toronto</li></settlement><orgName><li>Université d'Oxford</li><li>Université de Toronto</li></orgName></list><tree><country name="Australie"><noRegion><name sortKey="Malhi, Gin S" sort="Malhi, Gin S" uniqKey="Malhi G" first="Gin S" last="Malhi">Gin S. Malhi</name></noRegion><name sortKey="Byrow, Yulisha" sort="Byrow, Yulisha" uniqKey="Byrow Y" first="Yulisha" last="Byrow">Yulisha Byrow</name></country><country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Cassidy, Frederick" sort="Cassidy, Frederick" uniqKey="Cassidy F" first="Frederick" last="Cassidy">Frederick Cassidy</name></region><name sortKey="Frye, Mark A" sort="Frye, Mark A" uniqKey="Frye M" first="Mark A" last="Frye">Mark A. Frye</name><name sortKey="Gitlin, Michael" sort="Gitlin, Michael" uniqKey="Gitlin M" first="Michael" last="Gitlin">Michael Gitlin</name><name sortKey="Ketter, Terence A" sort="Ketter, Terence A" uniqKey="Ketter T" first="Terence A" last="Ketter">Terence A. Ketter</name><name sortKey="Ostacher, Michael J" sort="Ostacher, Michael J" uniqKey="Ostacher M" first="Michael J" last="Ostacher">Michael J. Ostacher</name><name sortKey="Thase, Michael E" sort="Thase, Michael E" uniqKey="Thase M" first="Michael E" last="Thase">Michael E. Thase</name><name sortKey="Tohen, Mauricio" sort="Tohen, Mauricio" uniqKey="Tohen M" first="Mauricio" last="Tohen">Mauricio Tohen</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Cipriani, Andrea" sort="Cipriani, Andrea" uniqKey="Cipriani A" first="Andrea" last="Cipriani">Andrea Cipriani</name></region><name sortKey="Mcshane, Rupert" sort="Mcshane, Rupert" uniqKey="Mcshane R" first="Rupert" last="Mcshane">Rupert Mcshane</name><name sortKey="Mitchell, Alex J" sort="Mitchell, Alex J" uniqKey="Mitchell A" first="Alex J" last="Mitchell">Alex J. Mitchell</name></country><country name="Belgique"><noRegion><name sortKey="Demyttenaere, Koen" sort="Demyttenaere, Koen" uniqKey="Demyttenaere K" first="Koen" last="Demyttenaere">Koen Demyttenaere</name></noRegion></country><country name="Canada"><noRegion><name sortKey="Kennedy, Sidney H" sort="Kennedy, Sidney H" uniqKey="Kennedy S" first="Sidney H" last="Kennedy">Sidney H. Kennedy</name></noRegion><name sortKey="Lam, Raymond W" sort="Lam, Raymond W" uniqKey="Lam R" first="Raymond W" last="Lam">Raymond W. Lam</name><name sortKey="Rizvi, Sakina J" sort="Rizvi, Sakina J" uniqKey="Rizvi S" first="Sakina J" last="Rizvi">Sakina J. Rizvi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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